Too Much Leptin Leads to Overeating and Weight Gain
Leptin is a hormone released by fat cells that plays a key role in appetite control. The hormone tells the brain when a person is hungry and should eat, and also coordinates this with energy utilization (signaling to the brain that the body has enough energy stores). Known as an appetite-suppressing hormone, leptin levels are generally lower in thin people and higher in people with more body fat.
Chronically high leptin levels can cause the body to stop responding to it effects, which can cause overeating and weight gain. High levels often correlate with high levels of insulin.
A feeling of satiety or fullness is the result of leptin signaling to the brain that a person has had enough food. In obese individuals, this signal is not properly received, even though there is an abundance of leptin in the body.
Continuous high levels of leptin can cause the body to become “leptin resistant,” a mechanism in the body that is similar to insulin resistance.
Controlling leptin levels is important, as high levels can cause obesity and weight gain, which contribute to the development of prediabetes and diabetes.